Sevilla virtually assured themselves of a berth in the last eight when they crushed La Liga rivals Real Mallorca 5-0 in Palma, Alvaro Negredo scoring twice to set the 2010 winners on their way.
Valencia moved closer to a place in the quarter-finals and a possible meeting with Real when Dani Parejo and substitute Roberto Soldado struck in a 2-0 win at Osasuna in their last-16 first leg on Tuesday.