Matches will be staggered across four midweeks between 15 February and 16 March. Group winners (listed second) play the home leg second.
The final is at Wembley Stadium on May 28 while the Europa League final takes place in Dublin on May 18.
CHAMPIONS LEAGUE LAST 16 DRAW
Roma v Shakhtar Donetsk
AC Milan v Tottenham Hotspur
Valencia v Schalke 04
Internazionale v Bayern Munich
Lyon v Real Madrid
Arsenal v Barcelona
Marseille v Manchester United
Copenhagen v Chelsea
