Man United have won just three matches by a two-goal victory in their last 20. Both against lower-league teams.
Midtjylland had more shots than United in the first leg (11 to 10) despite only having 37% possession.
Man United have won three of their four European matches at home this season (D1).
Midtjylland drew 1-1 at Southampton earlier this season.
Memphis Depay has four goals from eight Champions/ Europa League matches this season.
Midtjylland have lost their last two European away games without scoring, conceding six goals in the process.