The Russian striker came off the bench with little over a quarter of an hour to score two goals that settled Spurs nerves after Jermain Defoe’s first-half opener.
Pavlyuchenko has found his first-team opportunities extremely limited by Spurs boss Harry Redknapp, and the pair have traded verbal blows via the media for much of the season.
However, the club denied the 28-year-old a return to Russia with Lokomotiv Moscow last week, and he was made use of to decisive effect when he replaced Defoe on 73 minutes.
Following the goalless draw between Manchester City and Liverpool, the win puts Tottenham back above their rivals on goal difference. Wigan remain just two points above the relegation zone in 15th.